Research shows polystyrene nanoplastics accelerate ovarian cancer growth by activating CDK4/6 pathways, with Palbociclib offering a potential countermeasure.

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Cyclin-dependent kinase (CDK)4/6 inhibitors are approved for the treatment of breast cancer, and they have more recently been used in patients with well ...

The limited capacity of adult mammalian cardiomyocytes to undergo cell division and proliferation is one of the key factors contributing to heart failure. In newborn mice, cardiac proliferation occurs ...

This important chronobiological study in mice suggests that light modulated activity of Cdk5 activity on the PKA-CaMK-CREB signaling pathway provides missing molecular mechanistic details to ...

Reporter probes meant to track cell activity might not be as accurate as once thought. Here, melanoma cells express the extracellular signal-regulated kinase (ERK) translocation reporter. Cells ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neural stem cells (NSCs) can give rise to both ...