This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Trilaciclib significantly reduced chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer, which authors say minimizes the need for supportive care.

This manuscript reports useful data suggesting a critical role of two cyclin-dependent ... cell fraction is greatly increased in iDKO specimens, however this is mostly due to the reduction of germ ...

Furthermore, cellular senescence, driven by DNA damage and disrupted cell cycle ... a dose-dependent increase in senescence markers, such as the cyclin-dependent kinase inhibitor p21 and the ...

To identify DUBs required for KIFC1-dependent centrosome clustering, we performed two parallel siRNA screens in the TNBC cell line BT549, using the frequency of multipolar mitoses and KIFC1 protein ...

Cyclin B3 in complex with Cdk1 (cyclin-dependent kinase 1) is essential to prevent an untimely arrest of vertebrate oocytes in meiosis I by targeting XErp1/Emi2 for degradation. Yet, the molecular ...

It will be therefore important to associate the dynamics of immune response with the activation of the different stress-dependent signaling pathways. Integrative single-cell molecular analyses are ...