Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases (CDKs) and cyclins. Recent work using gene-targeted mice has led to a revision of this model and ...

Cyclin-dependent kinases are a type of serine/threonine kinase which are activated by cyclins to drive the progress of the cell cycle. The cell cycle is a comprised of 4 stages, which are tightly ...

Phosphorylation by CDK-2-cyclin E complex prevents this inhibition and so progression from G1 to S phase can continue. Overall, cyclins are responsible for the progression of the cell cycle ...

Phosphorylation can have profound effects on protein conformation and function that regulate many cellular processes, including the complex cascade of events that control cell cycle progression ... an ...

the same size as DNA replication domains — a striking finding that was consistent with their occurring as a result of aberrant DNA re-replication during the S phase of the cell cycle.

SAN DIEGO, CA, USA I June 05, 2025 I Avenzo Therapeutics, Inc. (“Avenzo”), a clinical-stage biotechnology company developing next-generation oncology ...