Mechanistically, ENPP1 degrades cellular cyclic GMP-AMP (cGAMP), thereby blocking activation of the STING pathway and suppressing anti-tumor immune activity in the tumor microenvironment.

Cyclic GMP-AMP synthase (cGAS) is an essential adaptor protein required for the inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP and activate STING and the expression of ...

Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a potential contributor to cardiac dysfunction. This study was aimed at ...

An essential part of the immune system is its ability to detect foreign or aberrant cytosolic DNA, and cyclic GMP–AMP synthase (cGAS) is the major cytosolic DNA sensor that binds double-stranded ...

Thursday, the company reported that its first-in-class cyclic GMP-AMP synthase (cGAS) inhibitor succeeded in a phase 1 study, teeing up plans for the company to commence a phase 2 study in ...

the first cyclic GMP-AMP synthase (cGAS) inhibitor to successfully complete a first-in-human study. The Phase 1 trial evaluated the pharmacokinetics (PK), target engagement, safety, and ...

The Cyclic GMP-AMP Synthase pipeline drugs market research report outlays comprehensive information on the Cyclic GMP-AMP Synthase targeted therapeutics, complete with analysis by indications, stage ...

Chen’s key contribution was to identify a DNA-activated enzyme called cyclic GMP–AMP synthase (cGAS), which binds DNA and initiates inflammation. 1,2 As with all great discoveries, the ...

Chen led work that resulted in the discovery of a critical enzyme — cyclic GMP-AMP synthase (cGAS) — that acts like a fire alarm in the body. But instead of being tripped by smoke, cGAS ...

Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its ...

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway has emerged as a critical driver of inflammation in a variety of settings, such as virus infection, ...

One of its central components is the enzyme cyclic GMP-AMP synthase (cGAS), which acts as a sentinel, detecting foreign DNA and initiating an immune response. However, the immune system requires ...