Every day, our bodies perform around 330 billion cell divisions to keep us alive and functioning. These divisions rely on the ...

Every day, our bodies perform around 330 billion cell divisions to keep us alive and functioning. These divisions rely on the ...

For decades, researchers have wondered why some people with risky gene variants go on to develop Parkinson’s disease, while others do not. A new study may have just provided the most detailed answer ...

Every day, our bodies perform around 330 billion cell divisions to keep us alive and functioning. These divisions rely on the ...

More information: Sifeng Gu et al, Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens, Nature Communications (2025). DOI: 10.1038/s41467-025-59948-z ...

Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under ...

Results: Our CRISPRi screen identified 768 inhibitors of fibroblast activation and 818 genes that promote AdvFib activation (p-value < 0.05). Beyond the expected regulators of the cell cycle and other ...