The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 substrates, such as caffeine, clozapine, fluvoxamine, olanzapine, tacrine, and theophylline. Inhaled insulin ...

Cytochrome P450 (CYP) enzymes play a central role in the degradation of drugs. Particularly relevant for human drug metabolism are CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4. Due to genetic variations ...

In this case, xanthone demonstrated an inhibitory profile for CYP1A2 enzymes similar to fluconazole, being a substrate for metabolism through CYP2C19, CYP2C9, which may favor its elimination from the ...

Since the response to psychotropic medication is a complex trait, the identification of key phenotypic measures for its definition is still a major issue in psychiatry. As a consequence ...

Purpose: Gastric cancer (GC) ranks as the third most common cause of cancer related mortality and as the fifth most frequently diagnosed cancer globally. Less than 30% of people with GC survive for ...

At Perfecting Peds, we ask all caregivers to report all vitamins and supplements their children are taking. Patient case: A 17-year-old female with autism, insomnia, epilepsy, ADHD and anxiety.

Samples were incubated with chemiluminescent HRP substrate (Thermo Fisher Scientific, WBKLS0500), and related signals were detected by MiniChemi 610 Plus (Biogp). The following antibodies were used: β ...

EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, Scotland EH9 3FJ, U.K.

Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea ...