PAHs are potent inducers of the hepatic cytochrome P-450 ... an important consideration is how quickly the induction of CYP1A2 dissipates. The primary pharmacokinetic interactions with smoking ...

whether it is an enzyme inducer or inhibitor. This behavior can affect the bioavailability profile of active substances or drugs, administered concomitantly during therapeutic treatment. In this case, ...

Halda has advanced the next wave of induced proximity drugs into the clinic, expanding the case for bifunctional molecules that act by sticking two proteins together. Whereas the first act for ...

The MEPED regimen includes nuclear receptor agonists such as pioglitazone and dexamethasone, which counterbalance HL homeostasis, HL stress response inhibitors, everolimus and COX-2 inhibitor, and a ...

During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely ...