Likewise, coadministration of potent CYP1A2 inducers ... Coadministration of rasagiline and theophylline (a substrate of CYP1A2) does not alter the pharmacokinetics of either drug.

PAHs are potent inducers of the hepatic cytochrome P-450 (CYP ... The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 substrates, such as caffeine ...

Prelude Therapeutics Inc. has described proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase binding moiety covalently linked to a probable global ...

A full run-through of all Remembrance quests for each of the eight Nightfarer classes in Elden Ring Nightreign.

The common types of medication you shouldn’t have with coffee. While your morning brew might feel harmless, it can interact with certain medicines to reduce effectiveness or increase side effects ...

Herein, we describe the design, synthesis, and in vitro biological evaluation of HO-1 inducers endowed with cytotoxic effects mediated by ferroptosis activation. Using the natural HO-1 inducer caffeic ...

The scientists also looked at a gene called CYP1A2. This gene controls how fast your body breaks down caffeine. Genes decide if coffee helps or harms. Some people break down caffeine quickly. They ...

Coadministration of apixaban with rifampicin, a strong inducer of both CYP3A4 and Pgp, led to a decrease of 54% in mean apixaban AUC and a decrease of 42% in maximum plasma apixaban concentration. The ...

On-demand content will be available for this poster session, available from Friday, June 6, 2025, 12:00 pm (ET) / 18:00 pm (CEST) About KERENDIA ® (finerenone) 1. KERENDIA is a non-steroidal ...

An essential function of the human epidermis is the maintenance of a protective barrier against the environment. As a consequence, keratinocytes, which make up this layer of the skin, undergo an ...