‘Much-needed hope’ as CRISPR gene editing therapy recommended for sickle cell disease
Experts hailed exciting news for some people with sickle cell disease in England as the health watchdog decided to grant ...
Nature24d
CRISPR-Cas9 genome editing articles from across Nature Portfolio
CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...
New Scientist2y
What is CRISPR?
When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...
The Scientist4mon
From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution
Cas9, the first Cas protein repurposed for cutting DNA, introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, ...
The Scientist1y
Avoiding Gene Editing’s Unintended Consequences
CRISPR-Cas9 editing leads to widespread loss of the targeted chromosome in human T cells, but scientists recently discovered a way to prevent such loss. To investigate how Cas9 gene editing affected T ...
After inversion by CRISPR/Cas, the epigenetic state of plant chromosomes remains stable
The epigenetic state of chromatin, gene activity, and chromosomal positions are interrelated. A research team from the IPK ...