Estrogen-associated COX-2 Pathways Explain Protection From Heart Disease In Female Mice. ScienceDaily. Retrieved June 4, 2025 from www.sciencedaily.com / releases / 2004 / 11 / 041123212242.htm.

Because of the direct links among estrogen, COX-2 pathways, and atheroprotection in female mice, this study raises concern about the use of COX-2 inhibitors in premenopausal women.

Experimental & Molecular Medicine - AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. Skip to main content.

FitzGerald's research investigated another target for anti-inflammatory drugs. Prostaglandin E2, also produced in the COX-2 pathway, has mixed effects, he said. Prostaglandin E2 is made by an enzyme ...

Researchers already knew that COX-2 can produce prostaglandins independently of iNOS. But the Hopkins study showed that iNOS is responsible for about half the total amount of prostaglandins that ...

August 30, 2007 (Farmingham, CT) – A new mouse study published this week provides some insight into understanding why rofecoxib (Vioxx, Merck) and the other cyclooxygenase (COX)-2 inhibitors ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ...

Yang, Z., et al. (2025). Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury.

COX-2, the inducible isoform of cyclooxygenase, is overexpressed in early and advanced CRC tissues, which portends a poor prognosis. Experimental studies have thus identified important mechanisms and ...

May 23, 2007 — The effect of aspirin (acetylsalicylic acid) in preventing colorectal cancer is restricted only to tumors that are COX-2-postive, a new analysis concludes. Taking aspirin ...

Our earlier studies demonstrated that COX-2 inhibition by NSAIDs down-regulated major KSHV latency gene LANA-1 and exogenous PGE2 reversed this effect. Here, we examined the role of COX-2/PGE2/EP ...

Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer: implications for tumor angiogenesis and metastases. Neoplasia 2001;3:53–61.