All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

The cyclooxygenase-2 inhibitors are non-steroidal anti-inflammatory drugs used as an analgesic for many disorders. The COX-2 enzyme is predominantly located in the central nervous system and thus ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...

Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx -- are no longer sold because of concerns ...

The COX-2 inhibitors shot to pharmaceutical fame in December 1998 ... Five months later Vioxx (rofecoxib) followed, approved for osteoarthritis, acute pain, and dysmenorrhea.1 But the use for ...

The league table listing the 'top 20' drugs includes rofecoxib (Vioxx) and celecoxib (Celebrex), two inhibitors of the prostaglandin-forming cyclooxygenase (COX) (Fig. 1), which between them ...

The study demonstrates that cyclooxygenase 1 (COX-1) inhibitors, including aspirin, enhance immunity to cancer metastasis by releasing T cells from suppression by platelet-derived thromboxane A2 ...

Selectivity of NSAIDs is currently based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/ or COX-2). IC 50 values provide no indication of the ...