Further complexity also arises because arachidonic acid at concentrations of 50 nM–1 µM acts at an allosteric site on the COX-1 enzyme, decreasing the affinity of COX-1 inhibitors but not COX-2 ...

The COX-2 enzyme is predominantly located in the central nervous system and thus there are fewer gastrointestinal side-effects with these drugs compared to COX-1 inhibitors.

COX-2 inhibitors are primarily used to treat pain in conditions such as arthritis. They work by blocking the COX-2 enzyme, which is expressed at sites of inflammation and underlies the production ...

The 15 invited conference speakers reported their most current findings on cyxlooxygenase (COX-1 and COX-2) inhibitor research including the latest technical developments concerning the relevance of ...

COX-2 is readily induced by cytokines and mitogens and accounts largely for prostaglandin formation in inflammation and cancer. A COX-1 variant, termed COX-3, has recently been described.

COX-2 Inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAIDs) that treat inflammatory pain.

COX–2 Inhibitors act by selectively inhibiting the transformation of arachidonic acid into prostaglandin H2 without affecting the COX–1 enzyme receptors.

Research from the University of Newcastle in New South Wales question the panic a few months ago about the so-called Cox 2 inhibitors, medications like celebrex and vioxx.

Taken as a whole, new findings suggest that COX-2 inhibitors may be beneficial for the prevention of renal damage in obesity-related Type II diabetes.

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...

Augusta University has patented NSAID derivatives acting as prostaglandin G/H synthase 1 (PTGS1; COX-1) and/or COX-2 inhibitors potentially useful for the treatment of inflammation and pain.

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...