All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...

Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx -- are no longer sold because of concerns ...

A new international clinical trial led by the National Cancer Center Singapore is reporting that three years of aspirin following standard adjuvant therapy for high-risk Dukes' B and C colorectal ...

Although the effects of anti-inflammatory drugs have been well studied, little is known about the signaling pathways involved in the inflammatory response. The recent finding that cyclopentenone ...

The mechanism of action of the ibuprofen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Famotidine is a competitive inhibitor ...

Selectivity of NSAIDs is currently based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/ or COX-2). IC 50 values provide no indication of the ...

As a COX-1 and COX-2 inhibitor, it has shown potential for reducing polyp recurrence and colorectal cancer risk in hereditary syndromes, with evidence well supported by prior randomized trials.