A tophus is a knobbly aggregate of uric acid crystals (monosodium urate monohydrate crystals) producing a foreign-body response (1). They may occur in any anatomical location, but most commonly around ...

Methods: In 18 patients with monosodium urate (MSU) crystal proven gout, and after the initiation of successful serum uric acid (SUA)-lowering treatment, an arthrocentesis of the asymptomatic signal ...

The gold-standard technique to diagnose gout and pseudogout is detection of crystals in joint fluid aspirates under compensated polarised light microscopy (CPLM). Detecting monosodium urate (MSU) and ...

Crystal differentiation revealed higher synovial fluid concentrations of IL-15, IL-1ra, IL-10, GM-CSF, PDGF-AB/BB and MIP-1b in patients with CPP- compared to BCP-calcified cartilage. Conclusion: We ...

When synovial fluid is low, which tends to happen with age, it can contribute to joint stiffness and other aging-related joint conditions like osteoarthritis. The makeup of synovial fluid can also ...

Objective Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Adding to studies focused on the role of T cells and macrophages, we sought to investigate the systemic ...

Machine learning can be combined with Raman spectroscopy to objectively identify gout-causing crystals in synovial fluid and diagnose the condition with high certainty, according to data published ...

Researchers conducted a retrospective study automating the identification process of MSU and CPP crystals in synovial fluid using machine learning techniques. They tested the system in a real-world ...

The following is a summary of “Discovery of calcite as a new pro-inflammatory calcium-containing crystal in human osteoarthritic synovial fluid,” published in the May 2024 issue of Rheumatology by ...

MICBOSCOPICAL examination of synovial fluid for identification of crystals is frequently performed for the diagnosis of gout or pseudogout (chondrocalcinosis). Problems may arise in the differentia ...

Synovial fluid crystal analysis can be performed using a gout analyzer for diagnosis of gout and calcium pyrophosphate deposition (CPPD) with certainty, in the absence of a standard compensated ...