Objective The aetiology of primary biliary cirrhosis (PBC) is largely unknown. Previous studies have indicated that both environmental and genetic risk factors may be important. Design We undertook a ...

We hypothesize that BIFNAR mice would be specifically protected from splenomegaly, B cell activation, and ANA production, due to IFN-s known ability to enhance the antibody response.Methods To examine ...

Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression. Hepatology 29 , 1007–1012 (1999). Article CAS Google Scholar ...

Many clinical trials in patients with PBC lack hard endpoints, because the disease is uncommon and slowly progressive. This Viewpoint discusses the importance of trial design in this field.

JAK2 is a promising target for treating myeloproliferative neoplasms (MPNs). However, existing JAK2 inhibitors cannot fully cure these diseases and may induce resistance with prolonged use. Here, we ...

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of autoimmune etiology, predominantly affecting middle-aged women. Its prevalence varies by geographic region, from 0.7 to 49 ...

Background: Hypercholesterolaemia often occurs in primary biliary cirrhosis (PBC) as a result of chronic cholestasis, but whether these patients are exposed to greater cardiovascular risk is unknown.

Repeated injury to the liver can cause liver fibrosis with end -stage cirrhosis being the 12th leading cause of death in the United States. Earlier stages of liver fibrosis can be reversed with ...

This is a surgery that involves taking out your spleen. Despite these findings, splenectomy isn’t considered a common treatment for cirrhosis. More research is needed to fully understand its ...

Cirrhosis is not reversible, but liver donation is one option to help manage symptoms and prevent complications. Here's what you should know.

Background: FF-10832 has demonstrated improved pre-clinical anti-tumor activity compared to gemcitabine (GEM). Associated factors may include its prolonged circulating half-life, tumor accumulation, ...