Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. + ...

The effects of aspirin, nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase (COX)-2 specific inhibitors on prostaglandins (PGD2, PGF2a, PGE2, PGH2) synthesis PGI ...

A NEW study reveals that inhibitors of cyclooxygenase 1 (COX-1), including the common drug aspirin, could enhance immune responses to cancer metastasis, offering hope for preventing recurrence in ...

Because of these roles, drugs that inhibit COX-1 can cause unwanted side effects. COX-2 inhibitors are a type of NSAID that selectively blocks the COX-2 enzyme and not the COX-1 enzyme. The goal of ...

Aspirin was introduced into clinical medicine ... At the same time, there was sufficient evidence to suggest a link between COX inhibition and adverse gastrointestinal and renal effects.

A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for preventing cancer or its recurrence. Gary J. Kelloff, chief of the chemoprevention ...

Despite the paucity of data for COX-2 inhibitors and investigated agents, including aspirin, minocycline, and statins, with purported pleiotropic anti-inflammatory mechanisms, further research is ...