Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Through base editing, drugs replace single nucleotide in the DNA strand with another ... 2b data with a monthly dose of its PCSK9-targeting antisense drug AZD8233. Meanwhile, Merck & Co is ...

Antisense,Backward Direction,Backward Flow,Behavioral Model,Cerevisiae,DNA Strand,Density Index,Density Profile,Elongation Rate,End Groups,End Of Strand,Flow Model ...

The exon-rich region is usually selected as the interfering region (500-700 bp), the sense strand is selected as the target gene for forward interfering sequences (RNAi, sense), and the antisense ...

Japan's Ono Pharmaceutical is handing over $280 million upfront to acquire Ionis Pharmaceuticals’ phase 2-stage antisense oligonucleotide for a rare type of blood cancer. The RNA-targeted ...

In just a matter of days, police have identified a handful of people for violating the county-wide burn ban, something county leaders say they’re taking seriously given the efforts they’re ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Herpesviruses require the host transcriptional ...

We’re back with a favorite in this week’s Dining with Dockery. We’re at River Oaks Pizzeria to show you new menu items and what makes this place so special.

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene ...