g) INS MODY (MODY 10): INS gene (11p15.5), preproinsulin. Mutations lead to misfolded proinsulin. h) ABCC8 MODY (MODY 12): ABCC8 gene (11p15), SUR1 protein. Regulates insulin secretion. Associated ...

A new study published in Communications Medicine details the discovery of rare gene variants that increase the prevalence of type 2 diabetes in multiple generations of Asian Indian people.

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes.

Higher prevalence of obesity and overweight without an adverse metabolic profile in girls with central precocious puberty compared to girls with early puberty, regardless of GnRH analogue treatment.