Moreover, during the passage of patient-derived cancer tissue into mice, PDXs often lose crucial stromal characteristics, resulting in alterations in the properties of the tumor microenvironment.

Scientists have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinted tumor models. These capabilities are enabled by the addition of Laponite ...

The TME is a complex and dynamic environment incorporating not only the cancer cells but also surrounding cancer-associated fibroblasts, immune cells, extracellular matrix components and other ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread. 4mo. ... and interactions with immune and stromal cells that are critical for metastasis.

3D multiplexed imaging in cancer immunology enables a better characterization of tissue ... We selected a set of targets to interrogate the immune tumor microenvironment 7: T cells (CD4, CD8 ...

More information: Tancredi Massimo Pentimalli et al, Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment, Cell Systems (2025 ...

How whole-tissue imaging of the tumor microenvironment can provide insight into the immune environment of specific cancer types. How AI-driven image analysis and advanced spatial analytics can be ...

Most Detailed 3D Tumor Atlases Reveal Immune “Hot Zones” And ... This microscope image shows a breast tumor and its surrounding microenvironment, something the new 3D atlases are giving ...

Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression. A tumor subpopulation called liver cancer stem cells (CSCs) significantly accounts for ...

Additionally, circadian rhythms influence the tumor immune microenvironment and the efficacy of anticancer therapies, paving the way for potential rhythm-based precision treatments.

The tumor microenvironment plays a crucial role in cancer. Discover how 3D models and organ-on-a-chip technology improve research and treatment. ... Optimizing Cell Culture Models To Mimic the Tumor ...