NFL Week 15 picks and predictions, straight-up and ATS: Bills-Patriots, Packers-Broncos lead huge slate The Indianapolis Colts pulling Philip Rivers out of retirement has the potential to be the story of the year for the NFL.

The Packers are coming off a last-second win over the Chicago Bears, wh ich thrust them back atop the NFC North and the No. 2 seed in the NFC. They've garnered tons of momentum with that victory, which, if you've been paying attention to the Packers this season, is exactly the time they give it all back with a loss.

An impactful Week 15 slate features five games that could go a long way in deciding division-winners and the No. 1 seed in each conference.

Notable odds: The Rams are essentially a lock to make the playoffs (97% odds on NFL.com), but they are still in a very tight race with the Seahawks and 49ers in the NFC West. The No. 1 seed isn't a lock by any means but the Rams are the favorites, per The Athletic's playoff odds, at 48%.

Meanwhile, both the Los Angeles Rams and Denver Broncos leapt to the No. 1 seed in their respective conference thanks to the events of Week 14. Of course, the season-ending Achilles injury to Colts quarterback Daniel Jones also has ramifications that'll also help reshape the postseason from here on out.

Our comprehensive Giants vs. Patriots predictions cover all sorts of angles for tonight's MNF matchup, including side bets, TD scorers, and player props!