Signalling between Notch receptors and ligands influences many differentiation processes and cell-fate decisions during embryonic and postnatal development. Stem-cell maintenance, binary cell-fate ...

Human mutations in Notch signalling components have been implicated in several forms of congenital cardiovascular disease, including cardiac outflow tract defects (jagged 1, notch 2), aortic valve ...

Bladder cancers (BCs) that invade the muscle layer are classified as muscle-invasive bladder cancers (MIBCs). The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

The researchers outfitted CD4+ T cells with synthetic Notch (synNotch) receptors—highly programmable chimeric receptors that detect target antigens and when bound, prompt the cell to release tailored ...