Aspirin was introduced into clinical medicine ... At the same time, there was sufficient evidence to suggest a link between COX inhibition and adverse gastrointestinal and renal effects.

The study demonstrates that cyclooxygenase 1 (COX-1) inhibitors, including aspirin, enhance immunity to cancer metastasis by ...

1). This statistic might seem surprising — after all, the therapeutic use of COX inhibitors has a venerable history dating back to the introduction of aspirin in 1898 (or even earlier if the use ...

Both beneficial and adverse effects are due to the same mechanism of action, which is inhibition of COX-dependent prostanoids ... or naproxen + PPI); if aspirin is indicated, naproxen + PPI ...