Aspirin and COX-1 inhibitors boost immunity against cancer metastasis, revealing a new pathway for anti-metastatic therapies.

Aspirin was introduced into clinical medicine ... At the same time, there was sufficient evidence to suggest a link between COX inhibition and adverse gastrointestinal and renal effects.

The study demonstrates that cyclooxygenase 1 (COX-1) inhibitors, including aspirin, enhance immunity to cancer metastasis by ...

Research has led to a new understanding of how aspirin stimulates the immune system to reduce the metastasis of some early ...

Both beneficial and adverse effects are due to the same mechanism of action, which is inhibition of COX-dependent prostanoids ... or naproxen + PPI); if aspirin is indicated, naproxen + PPI ...