The results presented here show the efficacy of single-molecule fluorescence for unraveling the dynamic and mechanistic details of translation. aa-tRNA delivery at the A site of the ribosome ...

However, emerging evidence suggests that tRNAs have a more central role in a stress response paradigm by functioning directly as signalling molecules in adaptive translation. tRNA composition ...

Biologists have directly observed the birth of a tRNA gene, using experimental evolution of bacterial populations in the laboratory. Translation is the process by which genetic information is ...

An experimental therapy that uses suppressor transfer RNA (tRNA) could help overwrite these ... attract molecules that help wind down translation, Ahern says. And in the instances where the ...

Alltrna is the latest in a growing number of startups with plans to develop therapies based on transfer RNA (tRNA), a family ... found in cells to control translation and either boost or reduce ...

The study highlights the importance of a universal tRNA modification for translation of specific codons. With these insights, the research team aims to explore whether preventing the decline of ...

Mitochondrial Glu-5'tsRNA-CTC disrupts the binding of mt-tRNALeu and leucyl-tRNA synthetase 2 (LARS2), impairing mt-tRNALeu aminoacylation and mitochondrial-encoded protein translation.