We've seen a No. 16 seed beat a No. 1 seed twice. We've double-digit seeds reach the Final Four. We've seen buzzer-beaters end careers. It's tough to predict what unlikely outcomes we will be treated to during the next three weeks.

The first step in filling out a March Madness bracket is plugging in the winners of the First Four games. Here's who's favored on Tuesday, Wednesday.

NCAA Tournament First Four matchup between the American Eagles and Mount St. Mary's Mountaineers with predictions, odds, picks, spread, betting lines and more.