Madness picks, predictions, odds for Houston Cougars vs Duke Blue Devils NCAA Tournament bracket men's Final Four game Saturday, April 5, 2025.

The four teams participating in the Final Four this weekend in San Antonio are a perfect microcosm of the new era in college basketball. While a team such as Duke has built its roster with former blue-chip recruits such as Cooper Flagg,

Who will win the NCAA Tournament Final Four game and advance to the national championship game in the NCAA bracket?Start the day smarter. Get all the news you need in your inbox each morning.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

Gillis came off the bench in his fourth season with the Boilermakers last winter, the same role he has with Duke. His numbers have dropped this year slightly — going from 6.5 points to 4.2, 3.9 rebounds to 2.6 and 21.2 minutes to 15.0.

If Duke wins it all, one bettor could turn a $5, five-leg parlay into a huge payday, complementing the $20k they've already made. Patrick Everson has the scoop.

There are no real edges for any of these teams as the matchups fit their playing styles. Duke and Houston have the two best defenses in the country and play slower, so fitting they meet, while Auburn and Florida both play at quicker tempos and rank as the second and third-best offenses behind Duke.

Duke enters Final Four as a worthy favorite, but how can you ignore Houston's experience, defense and grit? Beware the upset!

Cooper Flagg's point total is sky-high for this battle of No. 1 seeds when you consider what the Houston Cougars defense can do to the Duke Blue Devils attack, per Jason Logan's Final Four picks.