"There's a lot of historical data that indicated that the WNT signaling pathway would be important for maintaining the blood-brain barrier," Kuo said. "The opportunity arose to test a novel WNT ...

Deregulation of WNT signaling is associated with various cancers including GBM, which is the most malignant primary brain cancer ... that lead to aberrant WNT pathway activation in GBM, (2 ...

The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...

In agreement with these observations in animal models, they found that Wnt signaling ... the Wnt/Wg pathway. However, in NEDAMSS patients, with the loss of IRF2BPL, the levels of Wnt in astrocytes – a ...

Photodynamic therapy (PDT) resistance limits treatment efficacy in oral leukoplakia (OLK). This study identifies p-NRF2 as a ...

The pathway, Wnt signaling, is known to play a critical ... The researchers validated their findings by examining postmortem brain tissue from Alzheimer's patients -- they found that LRP6 levels ...

These proteins then go on define almost everything in the ecosystem of the body, from tissue growth to brain function. The Wnt signaling pathway, in particular, is especially active during ...

Researchers at the University of Illinois, Urbana-Champaign, developed an approach using blue light to activate the Wnt signaling pathway in frog embryos. The pathway plays a wide variety of roles ...

USP7 inhibition/depletion inhibits Wnt signaling in APC mutant colorectal cancers by restoring β-catenin ubiquitination – the addition of ubiquitin flags β-catenin for degradation via the proteasome ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data. The results, published ...

These proteins then go on define almost everything in the ecosystem of the body, from tissue growth to brain function. The Wnt signaling pathway, in particular, is especially active during ...