Once the cofactor is added, the enzyme becomes the active “holoenzyme”. Cofactors can either be ions, such as zinc and iron ions, or organic molecules, such as vitamins or vitamin-derived ...

More information: Zehui Guo et al, Peptide bridging for cofactor channeling in fusion enzyme lowers cofactor input by two orders of magnitude, Chinese Journal of Catalysis (2025). DOI: 10.1016 ...

Some enzymes cannot function unless they attach to a specific non-protein molecule, known as cofactors. There are two types Trusted Source of cofactors, ions and coenzymes.

Many enzymes require cofactors such as nicotinamide adenosine dinucleotide (NAD +) or nicotinamide adenosine dinucleotide phosphate (NADP +) to shuttle electrons between reactions.Artificial redox ...

An enzyme cofactor with a split personality Anthony Mittermaier 1 Nature Structural & Molecular Biology volume 22 , pages 101–103 ( 2015 ) Cite this article ...

Scientists describe a novel protein that spurs the post-translational modifications of the amino acid tryptophan to create an enzyme cofactor. This work may lead to the creation of new biological ...

It implies that the cofactor input can be decreased by two orders of magnitude (to 1/150) by using FuE-R5 instead of MFEc, and the fusion enzyme can efficiently work at a sub-stoichiometric NADP ...

Flavin mononucleotide (FMNH 2) is a common enzyme cofactor that is derived from riboflavin (vitamin B2).White et al. 1 show that the bacterial UbiX enzyme and the fungal Pad1 enzyme modify FMNH 2 ...

There, a third enzyme converts PTP into a well-known enzyme cofactor, called tetrahydrobiopterin (BH4). BH4 is required in the neurons that produce NPF, a neuropeptide that regulates feeding.

Osaka University scientists describe a novel protein that spurs the post-translational modifications of the amino acid tryptophan to create an enzyme cofactor. This work may lead to the creation ...

Enzyme fusion is a commonly used cofactor regeneration strategy, but the high usage and limited cofactor recovery restrict the sustainability of the catalytic process. Thus, there is an urgent ...