To break down and recycle these nutrients, the cells rely on tiny organelles called lysosomes. When functional, a lysosome ...

Dr. Dominic Winter is researching how this “recycling center” works – and how defects in its composition play a role in cancer. The German Research Foundation has awarded Winter a Heisenberg ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for ...

Lysosomes digest excess or worn-out organelles, food particles, and engulf viruses or bacteria. The membrane around a lysosome allows the digestive enzymes to work at the 4.5 pH they require.

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nature Communications , 2022; 13 (1) DOI: 10.1038/s41467-022-33025-1 Cite This Page : ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

Enzymes and lysosomes People with lysosomal storage disorders lack important enzymes (proteins that speed up reactions in the body). Without those enzymes, the lysosome isn't able to break down ...

However, lysosome damage is associated with aging and a range of diseases, including neurodegenerative disorders. In healthy cells, any damage to the protective membrane is quickly repaired. So, ...

The team discovered that peroxidation of lysosomes plays a key role in the execution of ferroptosis-mediated cell death. Additionally, they found that lysosomal lipid peroxidation causes the membrane ...