Lysosomes, often reductively referred to as the "garbage disposals" of cells, play a pivotal role in our cells' digestive systems by getting rid of unwanted materials. Now in a groundbreaking ...

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

The autophagosome then fuses with another type of vesicle called a lysosome. The fused stage is called an autolysosome. The autolysosome ultimately matures into a lysosome, where the waste is ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...