Can you briefly explain the concept of replication stress and its role in DNA repair? Liu: It's a really complicated topic. In really broad terms, replication stress is when the process of DNA ...

Replication stress can be caused by extracellular and intracellular sources during DNA replication, which leads to slowed or stalled replication. If cells do not properly cope with such risks ...

One source of this stress is when the bio-machinery that ... targets in cancer—working to understand their influence on DNA ...

Challenges to DNA replication arising from endogenous or exogenous sources, known as replication stress, can compromise genome integrity and lead to human diseases and cancer development.

It is said to be found during the start of a gene. DNA replication occurs in the S phase of the cell cycle. DNA replication is the process where DNA copies itself. This happens so that old ...

DNA replication is a process that occurs when DNA in the cells copies itself. This helps ensure that each new cell has its own complete genome during cell division. Doctors can only treat the ...

These “escapee” cells exhibited DNA replication deficits, accumulated DNA lesions, and mounted a stress response that depended on the ataxia telangiectasia and RAD3-related (ATR) kinase. We further ...

By uncovering how certain DNA structures drive replication stress, this work contributes to a better understanding of how cancer develops. It may also open the door to new treatment approaches ...

One source of this stress is when the bio-machinery that ... targets in cancer -- working to understand their influence on DNA replication. Additionally, the scientists unexpectedly captured ...