Whether identified as dicumarol or warfarin sodium, by complex molecular formulas or the brand ... Huebner were able to determine its chemical structure: 3,3’-methylenebis(4-hydroxycoumarin). In 1940, ...

The drug is called warfarin sodium. It prevents blood clots, and it can be a lifesaver for patients who've had a heart attack or stroke. It's one of the most widely prescribed drugs in the world.

Here we describe the crystal structure of a human CYP450, CYP2C9, both unliganded and in complex with the anti-coagulant drug warfarin. The structure defines unanticipated interactions between ...