The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

Alexander I. Spira, MD, PhD, FACP, discusses the clinical implications of ctDNA for treatment decisions and monitoring in ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window So, the subgroup analysis here is looking at variant allele frequency of ESR1 mutations and PIK3CA mutations.

Discover the connection between genetic risk factors for idiopathic pulmonary fibrosis and the development of post-COVID-19 ...

The current goals of the laboratory are two-fold: to develop better high-throughput systems for interrogation of variant allele function at scale, and to investigate the mechanisms of cancer oncogenes ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

Patients with more than one germline pathogenic variant (GPV) result in a clinical syndrome known as multilocus inherited neoplasia allele syndrome (MINAS). In recent years, an increasing number of ...