Once a protein is tagged for degradation or recycling, VCP threads the doomed protein through its central pore. There, if the protein is destined to be recycled, it must lose its functional tag ...

VCP associates with ubiquitinated proteins through the direct binding of its amino-terminal domain to the multi-ubiquitin chains of substrates. Furthermore, its N-terminal domain is required in Ub ...

In future studies, they plan to add the sort of protein that VCP would normally unfold, to see whether the VCP-VCPIP1 complex still behaves as predicted when actually doing its job.

This study from Dr. Edward Lee’s group provides an exciting glimpse into the potential role of valosin-containing protein (VCP) in ameliorating tau aggregation. The work highlights a novel ...

Researchers have identified a new protein involved in a defense mechanism against cancer. The VCP/p97 complex is best known for its role in protein destruction and is involved in a type of ...

In future studies, they plan to add the sort of protein that VCP would normally unfold, to see whether the VCP-VCPIP1 complex still behaves as predicted when actually doing its job.

A new research paper, titled "VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer," was ...

An enzyme as key to protein quality Date: May 9, 2025 Source: University of Würzburg Summary: In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's ...

A protein processing model. In pursuit of a structural model of VCP-DUB interactions, the team used single-molecule mass photometry to demonstrate that VCP forms a stable complex with a DUB called ...

Three dimensional cryo-EM structure of VCP (blue and purple) bound to three VCPIP1 promoters (red, orange, and yellow). Healthy cells are constantly breaking down proteins and building up new ones ...