During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Ubiquitination, a fundamental post-translational ... The review delves into the E3 ubiquitin ligases, a specialized class of enzymes responsible for targeting specific proteins for degradation ...

Figure 5: Parkin exhibits ubiquitination activity in vitro. Parkin consists of two functionally different domains (Fig. 6): the C-terminal RING-box, which recruits a specific E2 enzyme (UbcH7 ...

Luo and Qiu lead a research team that identified an enzyme that could independently accomplish ubiquitination, an important cellular signaling process being pursued as a therapeutic target.