WEHI researchers have solved a decades-long mystery by determining the structure of human PINK1, a key protein linked to ...

Every organism on Earth is a well-oiled machine in its own environment. It makes sense then that every piece of every process ...

Study reveals the structure of PINK1 protein, offering fresh hope for Parkinson's patients through potential targeted ...

Researchers have revealed for the first time how a key protein linked to Parkinson's mutates, leads to cell death in the ...

Melbourne-based researchers at the Walter and Eliza Hall Institute (WEHI) at the Parkinson's Disease Research Centre have ...

E6 associates with p53 and targets it for rapid degradation mediated by the ubiquitin ligase E6-associated protein (E6-AP), which does not recognize the free tumor suppressor. Inactivation of the ...

A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...

This discovery not only provides insights into the evolutionary arms race but also has practical applications for research into the human ubiquitin system. Thus, the treatment of cell or tissue ...

BPGbio CTO Vivek Vishnudas will present on the company's novel E2-based targeted protein degradation program at the TPD and ...

The effectors currently in use for targeted protein degradation and stabilization are E3 ubiquitin-ligases (E3s) and deubiquitinases (DUBs), respectively. E3 is an enzyme that transfers the ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...