This complex balances adhesion and guidance signaling to regulate neuronal migration timing and direction. This "push" signal is balanced by a "pull" signal, driven by the ubiquitin ligase ...

(APC = anaphase-promoting complex, CEN = centromeric DNA, and SCF = Skp, Cullin, F-box-containing ubiquitin-ligase complex.) ...

Parkin, PINK1 and DJ-1 operate in the same pathway; they can interact to create an ubiquitin–protein ligase complex. Substrates will need to be identified in stressed cells. Parkin binds to ...

Bin Wu, associate professor in the department of Biophysics and Biophysical Chemistry at the School of Medicine, visited ...

The tumor microenvironment is a complex ecosystem of tumor cells ... and metastasis. Multiple E3 ubiquitin ligases and ...

Neddylation is a post-translational modification that conjugates the NEDD8 protein to protein substrates, such as the cullins, which once neddylated join complex to form cullin-RING ubiquitin E3 ...