The Rumack–Matthew nomogram, first published in 1975, was developed to estimate the likelihood of hepatic injury due to acetaminophen toxicity for patients with a single ingestion at a known time.

The Rumack-Matthew nomogram, an important indicator of the need for treatment for acetaminophen overdose, is a reliable tool for single acute ingestions of the IR formulation. However, a single ...

We investigated the use of a 20-hour protocol of oral N-acetylcysteine for the management of acute ingestion of an acetaminophen ... at eight hours on the Rumack–Matthew nomogram), normal ...

A revised Rumack-Matthew nomogram was developed ... and refining the clinical roles of fomepizole and hemodialysis in acetaminophen poisoning," the authors write. More information: Richard ...

Clinicians should draw serum acetaminophen concentrations four ... If levels are above the treatment line on the Rumack-Matthew nomogram, clinicians should initiate treatment with acetylcysteine.