The kynurenine pathway is a crucial metabolic route for the amino acid tryptophan, leading to the production of several bioactive compounds that play significant roles in immune regulation and ...

The research highlights the complex role of tryptophan metabolism in cancer. While tryptophan is known to be metabolized into several important compounds, including the neurotransmitter serotonin ...

And the result “identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease.” “We ...

IDO is the rate-limiting enzyme in the tryptophan-to-kynurenine metabolic pathway. Accordingly, metabolomic analysis surveying 458 different metabolites revealed two molecules showing increased ...