Hessa et al., ?Recognition of transmembrane helices by the endoplasmic reticulum translocon,? Nature, 433:377?81, 2005. (Cited in 88 papers) The finding: Gunnar von Heijn Kerry served as The Scientist ...

Turning groundbreaking research from the Institut Pasteur with the support of Argobio’s start-up studio, into novel treatments for cancer, inflammatory diseases and viral infections. The platform ...

What components constitute the translocation machinery (translocon)? How is it assembled and what are its structural characteristics? How are the substrates recognized and selected? What are the ...

triggers release of the nascent chain and its insertion into a protein conducting channel (‘translocon’). Besides challenging the prevailing view of signal sequence recognition, the new ...

The translocon machineries, known as the TOC (translocon at the outer chloroplast membrane) and TIC (translocon at the inner chloroplast membrane) complexes, provide the route for preprotein ...

The platform leverages state-of-the-art generative artificial intelligence (AI) to design selective inhibitors of the Sec61/translocon molecular complex for blocking and degrading disease-causing ...