Topoisomerases are classified into several families, namely, types IA, IB, IC, IIA and IIB. These families have different cellular roles and preferential substrate specificities. Topoisomerases ...

Figure 7: Unexpected complexities in the type IIA topoisomerase catalytic cycle. Type IIA topoisomerases are multisubunit DNA-remodeling enzymes that undergo a series of highly articulated ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I ...