Selective cyclo-oxygenase (COX)-2 inhibitors were developed with the hope of producing lesser gastrointestinal (GI) side effects as compared with the conventional nonsteroidal anti-inflammatory ...

These inhibitors target the COX enzymes responsible for ... The review of recent developments emphasizes the need for novel selective COX-2 inhibitors that possess improved safety profiles ...

WEE1 may also be an important target for cancers with ... Debio 0123 is a next-generation WEE1 inhibitor with a distinct chemical structure that avoids targeting PLK1/2. “It’s a completely ...

With one selective cyclooxygenase (COX)-2 inhibitor–celecoxib–still available in the U.S. and another–etoricoxib–under review (Journal Watch Feb 21 2007), the gastrointestinal side-effect ...

Both are types of NSAIDs, but they work differently. Celebrex is a selective COX-2 inhibitor that targets inflammation with ...