Putting these pieces together, Dixon & Neurath concluded that the side chain of this ... carefully examined the structure of chymotrypsin, they found the histidine and serine amino acids described ...

This behaviour is driven by hydrogen bonding that involves the side-chain hydroxyl groups of the serine. A similar cooperative ... acids can radically alter structure and function.

The Paetzel lab investigates the structure and mechanism of proteases (peptidases ... lysine general base and an unusual oxyanion-hole made up of a serine side chain hydroxyl group and a main chain ...

This image illustrates the general structure of an amino acid.The central carbon atom (C) is bonded to a hydrogen atom (H), an amino group (NH2), a carboxyl group (COOH), and a variable side chain (R ...

For example, N-glycosylation (attachment of glycans to nitrogen on the amine side chain of asparagine) and O-glycosylation (attachment of glycans to oxygen on serine and/or threonine). Specific ...

To address the structural basis for this defect, we determined the 2.6 Å structure of the zymogen form of the G666E mutant of MASP-3. These data reveal that the mutation disrupts the active site and ...

the MBL-Associated Serine Proteases (MASPs). The crystal structures of the catalytic domains of MASP-1 and MASP-2 have been solved, but the structure of the corresponding domain of MASP-3 remains ...