A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

A specialized molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction.

Splicing twins: Unravelling the secrets of the minor spliceosome complex. European Molecular Biology Laboratory. Journal Molecular Cell DOI 10.1016/j.molcel.2024.12.017. Keywords ...

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...

The spliceosome complex removes intron sequences from RNA transcripts to form messenger RNA. The structure of a spliceosomal protein, Prp8, reveals the complex's active site and casts light on the ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...

A hPrp28 mutant stalls spliceosome assembly before complex B. To dissect the role of the DEAD-box protein hPrp28 during human spliceosomal B complex formation, we first assayed the effect of an ...

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA. A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after ...

The spliceosome complex was found to be interconnected, with disruptions in one portion having significant effects on other parts of the complex. "Their reliance on a highly interconnected splicing ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.