Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.

To investigate how Cas9 gene editing affected T cells ... Tsuchida and his colleagues used CRISPR-Cas9 to edit multiple genes on every somatic chromosome. They found that chromosome loss occurred for ...

Base editing utilizes enzymes to modify single amino acids at the most foundational unit of DNA, called a base.

We focus on the mouse as a model organism or the development of new technologies and preclinical testing of gene editing therapies ... of in vivo genome editing, developed in part through ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

The mutation in the huntingtin (HTT) gene, which causes the incurable ... They found that mutated HTT undergoes a process called “somatic expansion,” by which the number of CAG repeats ...

A novel in vivo screening strategy identifies new modifiers of somatic CAG repeat expansion ... Although compact Un1Cas12f1 has improved, low gene editing activity was observed in some target ...