Microscopic image of tissue cross-sections of a mouse brain with a glioblastoma. The tumor cells are shown in turquoise, the CAR-T cells injected into the tumor in yellow and the immune cells ...

3T Biosciences has developed an immune response-guided approach for identifying pharmacologically active T cell receptors and their targets in solid tumors ... and off-target cross-reactivities.

Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors and were among the first solid tumor types for which such a novel treatment (in this case imatinib) became available. The ...

Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful in hematologic malignancies, presents a promising avenue for treating solid tumors, including CRC. This review explores the ...