Since smallpox vaccines in development cannot be tested for clinical efficacy, the Animal Rule will most likely be used to evaluate the efficacy of new-generation smallpox vaccines, per 21 CFR 601.90.

Data on the number of cases for these diseases from the pre-vaccine era is hard to come by, and even the case counts are ...

Wondering why it's back in the news? While mpox often circulates in central and western Africa, the 2022 outbreak quickly spread from the Democratic Republic of the Congo to places it had never been ...

Canada has an opportunity to prevent sustained Clade I mpox transmission, but only if decisive action is taken now.

An unusual property of the smallpox virus is that it only infects humans and not animals and insects (this property was instrumental in the eradication of smallpox). After exposure to the virus, it ...

He found that milkmaids who developed cowpox through working close to the animals day after day seemed to be protected from smallpox, the human form of the disease. • In Britain, the disease was ...

Samples of smallpox virus are not needed for the production or further development of new vaccines or drugs because animal model poxviruses are used instead. If smallpox were to be genetically ...

They also stockpiled animal manure in the hope of spreading illness. Yet the defense held fast, and the siege was abandoned after five months. While the first true vaccine for smallpox was not ...

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Not so with smallpox. To create this vaccine, you begin with another virus that is similar to the smallpox virus, yet different enough not to bring on the smallpox disease once it enters your body.