As expected, the receptor consists of seven transmembrane helices connected ... The sequence identities are 21% overall and 23% in the transmembrane domains. For comparison, the r.m.s. deviation ...
Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.
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