While the drug’s full mechanism isn’t known, stimulation of those serotonin receptors may drive serotonin levels in reward-related areas of the brain down. This might in turn send dopamine ...

CIII allows people who have tried at least two oral antidepressants to use the spray on its own – without the need for more ...

Serotonin syndrome is a preventable, drug-related complication that results from increased brain-stem serotonin activity, usually precipitated by the use of one or more serotonergic drugs.

A Mayo Clinic neurosurgeon and his colleagues believe one form of that treatment, called deep brain stimulation (DBS), is poised to solve one of the greatest public health challenges: drug addiction.

The use of selective serotonin-reuptake inhibitor drugs, such as fluoxetine, for the treatment of PAH may improve survival in PAH patients, although larger clinical trials are required to verify this.

Mucosal stimulation in the gut, triggered by meals, activates tryptophan hydroxylase-1 (Tph1). Activation of this enzyme results in synthesis from tryptophan of serotonin that then diffuses into ...