The regulation and remodeling of the tumor microenvironment (TME) are closely associated with how cancers typically progress and metastasize. The extracellular matrix (ECM) is an intricate network ...

Study findings suggest that SA-HFIRE causes a dynamic shift in tumor lymphatic and blood microvascular structures, ...

City of Hope researchers have co-led the first study to demonstrate that characterizing genetic material near chromosomes ...

Recent innovations across the multiple ADC components, such as enhanced antibody-targeting to the tumors, better linker ...

Following Merus’ splash last month with a “best-in-disease profile” for its head and neck cancer bispecific, Bicara touted ...

While novel and more effective treatments continue to increase at a rapid rate, testing platforms that accurately mimic the tumor microenvironment (TME) are lacking. Tumors are complex ecosystems that ...

In the Phase 1/1b trial, ficerafusp alfa in combination with pembrolizumab resulted in deep and durable anti-tumor activity with improved overall survival (OS) compared to historical benchmarks in ...

“Anti-tumor immune cells are also challenged by nutrient limitation in tumors.” Nutrient limitation in the tumor microenvironment can lead to the metabolic suppression of effector immune cells, ...

fueled a myeloid-rich tumor microenvironment in mice, and resulted in the promotion of tumor organoid growth. TI-CH increased the risk of disease recurrence or death among patients with NSCLC and ...