These assays usually require labeling ... to reduce any background fluorescence signal. Internalization of an antibody to CD71 - the transferring receptor - was measured in HT1080 fibrosarcoma ...

As technology advances to the point at which various behaviours of seven-transmembrane (7TM) receptors (also known as G protein-coupled receptors (GPCRs)) can be observed individually, it is clear ...

G protein-coupled receptors (GPCR ... proteins presents an attractive technology to perform receptor internalization assays. When fused to SNAP-tag, Gq-coupled GPCRs Neurokinin-1 Receptor and ...

How real-time live-cell analysis of antibody internalization can provide additional insight. The use of the IncuCyte FabFluor-pH reagent to provide a turn-key approach to antibody labelling. Examples ...

For example, antibody drug conjugates (ADCs)—targeted therapies comprised of an antibody, a linker, and a toxin—rely on cell binding, internalization ... assay re-establishes T-cell receptor ...

Receptor mediated internalization is a key mechanism of ... We have developed a method that mitigates problems associated with traditional internalization assays. The method includes: 1) A water ...

Arialys Therapeutics' precision medicine has shown preclinical potential to address the underlying cause of anti-NMDA ...

Antibody internalization is a key element ... or controlled by recombinant ligands or receptors. Sino Biological can supply pseudovirus assays, immune checkpoints, and cytokine neutralizing ...

"These new assays provide researchers with robust tools to explore the functional interactions of compounds with key vasopressin receptors," said Bruce Sherf, Chief Technology Officer at INDIGO ...