1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a short part of the molecule, known as the seed region, pairs with the target, rather than the full ~20 ...

The RNAi pathway was first discovered in Caenorhabditis elegans; injection of double-stranded (ds) RNA into the worm initiated sequence-specific degradation of mRNAs that contain the same sequence ...

interferon pathway machinery) or nontargeted mRNAs. As a result, the standard of care to demonstrate the specificity of an observed RNAi-induced phenotype (namely the suppression of the targeted ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

In the RNA interference (RNAi) pathway, exogenous double-stranded RNA is converted into ~21 nt small interfering (siRNAs), which guide the cleavage and destruction of perfectly complementary ...

The presentation titled, "Targeting Obesity with RNAi-based Therapies," was included ... both seek to intervene in a known biological pathway with strong support from human genetics studies ...

Mingjiang Xu, found that RNA plays a significant role in how DNA is packaged and stored in your cells, via a gene known as TET2. This pathway also appears to explain a long-standing puzzle about ...

Arrowhead Pharmaceuticals’ phase 1/2a study has found the company’s investigational RNA interference (RNAi) candidate was generally well tolerated among 14 patients with kidney disease.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of ...