The RNAi pathway was first discovered in Caenorhabditis elegans; injection of double-stranded (ds) RNA into the worm initiated sequence-specific degradation of mRNAs that contain the same sequence ...

1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a short part of the molecule, known as the seed region, pairs with the target, rather than the full ~20 ...

Arrowhead Pharmaceuticals’ phase 1/2a study has found the company’s investigational RNA interference (RNAi) candidate was generally well tolerated among 14 patients with kidney disease. | Arrowhead ...

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced presentation of preclinical data supporting the advancement of two first-in-class clini ...

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

interferon pathway machinery) or nontargeted mRNAs. As a result, the standard of care to demonstrate the specificity of an observed RNAi-induced phenotype (namely the suppression of the targeted ...

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of ...

The presentation titled, "Targeting Obesity with RNAi-based Therapies," was included ... both seek to intervene in a known biological pathway with strong support from human genetics studies ...