The structure and chemistry of nucleic acids is fundamental to their function, from the DNA double helix discovered by Watson and Crick to the intricate secondary and tertiary structures adopted by ...

Nucleic acids are complex biological molecules that store and transmit ... to form the iconic double helix structure. RNA is usually single-stranded but can form complex secondary structures through ...

Adenine and guanine, the two most common purines in DNA and RNA, share this core structure, which is crucial for forming the base pairs in nucleic acids. (Image: Wikimedia Commons, Public Domain) ...

Levene made his initial proposal in 1919, discrediting other suggestions that had been put forth about the structure of nucleic acids. In Levene's own words, "New facts and new evidence may cause ...

A variety of chemical modifications decorate the nucleic acids, increasing the alphabet of DNA ... The different building blocks can affect the complementarity of the RNA molecules, alter their ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Determining structures of small, protein-free RNAs by cryo-EM has been challenging. Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand ...

48. Arteaga, S. J., Dolenz, B. J., and Znosko, B. M. (2024) "Competitive influence of alkali metals in the ion atmosphere on nucleic acid duplex stability," ACS Omega ...

LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs ... which all kinds of therapeutic nucleic acids can be encapsulated for secure ...

But the challenge is daunting: Each RNA molecule is tightly bound to ... helical nucleocapsid-like pseudo-atomic structure, Nucleic Acids Research (2024). DOI: 10.1093/nar/gkae1211 Provided ...

metabolism at the post-transcriptional level via a novel small noncoding RNA to promote infection in the host's intestinal environment. Sialic acids are a family of alpha-keto acid sugars with a ...